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Fentanyl is a potent opioid narcotic. It is similar to OxyContin and heroin, although it is much more intense. This narcotic medication is typically 50-100 times more powerful than morphine and around 50 times more potent than heroin.
This drug is a Schedule II medication, like other opioids, according to the Drug Enforcement Administration (DEA). This means that prescriptions for fentanyl are tightly restricted, but the medication is still an important part of pain management for many people. The most common prescription forms are Duragesic, Actiq, and Sublimaze; these are prescribed to treat severe chronic pain when the person has developed a tolerance to other painkillers or for pain related to cancer. They are never prescribed for moderate pain or pain that is expected to go away over time.
However, fentanyl is also manufactured illegally in clandestine laboratories and sold on the black market. Since around 2012, the introduction of illicit fentanyl into the United States has led to a rapid increase in overdose deaths. The drug is sold mixed into heroin or cocaine, and it is sometimes sold instead of either of these drugs. Since fentanyl is so much stronger than heroin, it can rapidly cause an overdose and death even among people who struggle with opioid addiction because users do not know how much of the drug to consume.
It is possible to taper off fentanyl, just like other opioids; however, if fentanyl has been prescribed to treat pain, it is unlikely that the person taking it will taper off with their doctor’s help. The drug is only prescribed to treat severe pain related to chronic health issues or cancer, with the expectation that the pain will be an ongoing concern.
However, there are reasons that a doctor may wean their patient off a fentanyl prescription.
When someone needs to taper off fentanyl, it is most often because they struggle with an addiction to opioids. A doctor overseeing the detox and tapering process could help ease the individual off the narcotic if it is a prescription drug. When narcotics are abused for nonmedical reasons, medication-assisted treatments (MATs) will be used to ease the withdrawal process.
When fentanyl is abused, like other opioid narcotics, it binds to the opioid receptors in the brain and interrupts the pain signals, so the person feels less pain. This also releases mood-elevating hormones like dopamine and serotonin, and it can impact how the body manages respiration rate, heart rate, and blood pressure. Neurotransmitters like serotonin and dopamine trigger the brain’s reward system, so the individual will feel better after taking these drugs. They will have a reduction in pain sensations, and they will have some mood elevation and relaxation, too.
For people who abuse opioids like fentanyl, these mood-elevating and relaxing effects are the triggers for addiction and abuse. Because fentanyl is so potent, abusing the drug can cause an intense euphoria that lasts for a long time.
Quitting can be very uncomfortable, which is why tapering with some form of MAT will be incredibly important.
The tapering process for fentanyl can depend on how long the individual abused the drug and how large their dose of the drug was. This can also impact which MAT a physician will choose to prescribe.
The Veterans Administration (VA) offers medical treatment to veterans for numerous health issues, including mental illness and addiction.
They recommend the following general tapering procedures for different forms of MAT:
Neither methadone nor buprenorphine will be prescribed for at least two days after the final dose of any opioid drug, including fentanyl. This is because a clinician must examine their patient’s withdrawal symptoms to understand how much of either MAT to apply and how long the taper’s duration should be.
The Centers for Disease Control and Prevention (CDC) also provides a general opioid medication tapering guideline.
Using a slow, individualized taper with medications like methadone or buprenorphine can reduce the impact of fentanyl withdrawal.
Symptoms of withdrawal from opioids like fentanyl include:
Someone who struggles with fentanyl addiction may suffer intense withdrawal symptoms, so it is important to work with an addiction specialist to safely detox from the drug using MAT and an appropriate tapering schedule.