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Psychedelic drugs are often classified as a subclass of the hallucinogens that result in altered perceptions and cognitions in individuals who take them. These drugs have an effect on the neurotransmitter serotonin and other neurotransmitters in the brain. These drugs were extremely popular in the 1960s and 1970s. They may be making somewhat of comeback today, although they have not approached the popularity they had decades ago.
This article will discuss the psychedelic drug LSD and its relationship to hallucinogenic-induced persistent perception disorder (HIPPD).
LSD is an abbreviation for its chemical name, lysergic acid diethylamide. LSD is capable of producing very realistic and vivid hallucinations (mostly visual) and extremely strong changes in mood in individuals who take very small amounts of the drug. There is quite a range of sensory perceptual experiences and mood states that occur in individuals who take this drug, and it most likely interacts with the individual’s expectations, past experiences, and biology to affect individuals in personalized manners. Users typically take very small amounts in a liquid form that can be ingested with certain types of edible papers or in a tablet form.
The drug was originally developed by a Swiss chemist named Albert Hoffman back in 1938. Hoffman was attempting to use different types of substances to assist in childbirth and was concentrating on the use of a fungus known as ergot for this purpose. He developed a number of different compounds, and LSD was the 25th of these compounds (its original designation was LSD-25). Hoffman was looking to develop the stimulant properties of the drug, but it did not meet his specifications and he abandoned his study of it until five years later. While working with the drug at this time he began to have visual hallucinations, a sense of euphoria, and dizziness. The following day he administered a small amount of the drug to himself (250 micrograms, which is actually a large amount of LSD to take). He became euphoric and experienced a number of different pleasant visual hallucinations. After administering it to other individuals in his laboratory group, he decided to market the drug as a therapeutic drug to psychiatrists.
The drug became quite popular in the 1960s and was responsible for a counterculture movement looking for various aids to enhance thinking and to expand consciousness. The compound was also used for treatment purposes in psychiatry, and some sources still report that it can be useful in the treatment of certain individuals. The drug eventually lost popularity due to a number of changing issues in the 1970s, including more conservative values regarding drug use.
Currently, the United States Drug Enforcement Administration (DEA) has LSD listed as a Schedule I controlled substance, which indicates that, according to the DEA, the drug has no medicinal uses and a high potential for abuse and the development of physical or psychological dependence (despite evidence to the contrary).
As mentioned above, LSD is a hallucinogen, fitting into a class of drugs that include other mind-altering drugs such as mescaline, PCP, and psilocybin (the ingredient in magic mushrooms). Individuals take the drug for its hallucinogenic and mood-altering effects. It is typically taken in very small doses between 100 and 200 micromilligrams. Even at such small doses, the effects can be long-lasting, and in some individuals, they can last for up to 12 hours. It is taken in pill form or ingested as a liquid on edible papers.
There are a number of case reports that indicate that even at extremely high doses, there are no serious physical long-term effects of LSD use. The majority of individuals in these studies experienced decreased respiration, increased body temperature, gastrointestinal issues (nausea, vomiting, or light bleeding in the intestine or stomach), and, in rare cases, unconsciousness, but all symptoms were readily addressed.
According to these studies, it does appear that individuals do develop tolerance to LSD, but there are no significant withdrawal symptoms, indicating that despite the classification by the DEA, the drug is not associated with a significant potential for the development of physical dependence. LSD does not appear to be a drug that is associated with high rates of diagnoses of substance use disorders (abuse and addiction), although there are certainly instances were individuals abuse the drug. Despite this, there are dangers associated with using the drug.
Despite a relatively innocuous body of research looking at the long-term effects of LSD use, there are some reports in the research literature that suggest the potential for issues.
The most common experiences of individuals having flashbacks are visual experiences, including seeing flashing lights, seeing different colors, seeing halos on people or objects, and other rather innocuous visual hallucinations. However, since flashbacks only occur when individuals have not used the drug, these experiences may be very distressing. Having one or two flashbacks is not the same as having HIPPD. An individual diagnosed with HIPPD has a defined clinical disorder that satisfies certain diagnostic criteria (see below). HIPPD is relatively rare and appears to occur in slightly over 4 percent of individuals who have used hallucinogenic drugs.
An HIPPD diagnosis requires the following:
The development of HIPPD is associated with both the flashback effect and a resulting effect on the person’s functioning or emotional wellbeing. There is very little understanding as to why this disorder develops in some people, and any potential causal factors are loosely described. There are a number of suggestions regarding the possible causes of HIPPD, including:
There appears to be no definitive forms of treatment to address the symptoms of HIPPD, and at this time, there is no cure associated with this disorder. Some sources suggest that the use of anticonvulsant medications can help, whereas other sources suggest the use of benzodiazepines might be helpful. Because the disorder is relatively rare, there are no large-scale, randomized, controlled trials looking at the treatment utility of different medications and other approaches at this time. Individuals with the disorder are addressed on a case-by-case basis.